2021-present
  • 2025
  • 2024
  • 2023
  • 2022
1. Huang Su#, Yifan Chen#, Xuyang Zhao#, Zengyi Lu, Tongxuan Wei, Qinguo Liu, Xiyang Liu, Qinhao Zhang, Siqi Bian, Da Xu, Liqin Zhang*. Systematic evolution of functional oligonucleotides for targeted protein degradation. Chem, 2025, online. doi.org/10.1016/j.chempr.2024.102408
2. Sharpkate Shaker#, Jun Li#, Shuo Wan#, *, Hong Xuan, Jinchen Long, Haiyan Cao, Tongxuan Wei, Qinguo Liu, Da Xu*,  Steven A Benner*, Liqin Zhang*. Cancer cell target discovery: comparing laboratory evolution of expanded DNA six-nucleotide alphabets with standard four-nucleotide alphabets. Nucleic Acids Research, 2025, 53, gkaf072. doi.org/10.1093/nar/gkaf072
3. Tongxuan Wei#, Qinguo Liu#, Jun Li#, Song Song, Liqin Zhang*. Functional Aptamers In Vitro Evolution for Protein−Protein Interaction Blockage. Analytical Chemistry, 2025, online. doi.org/10.1021/acs.analchem.4c04609
4. Hong Xuan#, Siqi Bian#, Qinguo Liu, Jun Li, Shaojin Li, Sharpkate Shaker, Haiyan Cao, Tongxuan Wei, Panzhu Yao, Yifan Chen, Xiyang Liu, Ruidong Xue, Youbo Zhang*, Liqin Zhang*. Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope, Acta Pharmaceutica Sinica B, 2025, online. doi.org/10.1016/j.apsb.2025.03.003

1. Yike Li, Shaohua Zhang*, Chao Liu, Jinqi Deng, Fei, Tian, Qiang Feng, Lili Qin, Lixiao Bai, Ting Fu, Liqin Zhang*, Yuguang Wang* and Jiashu Sun*. Thermophoretic Glycan Profiling of Extracellular Vesicles for Triple-negative Breast Cancer Management, Nature Communications, 2024, 15, 2292. doi.org/10.1038/s41467-024-46557-5
2. Jun Li, Panzhu Yao, Ke Tang, Xuyang Zhao, Xiyang Liu, Qinguo Liu, Tongxuan Wei, Hong Xuan, Siqi Bian, Ying Guo*, Zhenjun Yang*, Zhi-Qi Zhang*, and Liqin Zhang*. Functional Aptamers in vitro Evolution for intranuclear blockage of RNA-protein Interaction, Journal of the American Chemical Society, 2024, 146 (35), 24654-24662. doi.org/10.1021/jacs.4c08824
1. Xuyang Zhao, Yifan Chen, Huang Su, Liqin Zhang. From classic medicinal chemistry to state-of-the-art interdisciplinary medicine: Recent Advances in proteolysis-targeting chimeras technology. Interdisciplinary Medicine, 2023, 1(2), e20230004 doi.org/10.1002/INMD.20230004 (Invited Review)
1. Weihong Tan, Zilong Zhao, Liqin Zhang. Aptamer Properties, Functions, and Applications. In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications. Lihe Zhang, Xinjing Tang, Zhen Xi, Jyoti Chattopadhyaya, Eds.; John Wiley & Sons, Inc., 2022, pp 443-482.

2010-2020
  • 2010
  • 2012
  • 2014
  • 2015
  • 2016
  • 2017
  • 2018
  • 2019
  • 2020
1. Li-Qin Zhang, Ying-Dong Huang, Xiu-Wei Yang. Intestinal Permeability of Liquiritin and Isoliquiritin in the Caco-2 cell Monolayer Model. Journal of Chinese Pharmaceutical Sciences, 2010, 19(6), 451-458.
1. Li-Qin Zhang, Xiu-Wei Yang, You-Bo Zhang, Ya-Ya Zhai, Wei Xu, Bo Zhao, Dai-Lin Liu, Hong-Jian Yu. Biotransformation of Phlorizin by Human Intestinal Flora and Inhibition of Biotransformation Products on Tyrosinase Activity. Food Chemistry, 2012, 132(2), 936–942.
1. Kwame Sefah, Zunyi Yang, Kevin M Bradley, Shuichi Hoshika, Elizabeth Jimenez, Liqin Zhang, Guizhi Zhu, Savita Shanker, Fahong Yu, Weihong Tan and Steven A. Benner. In vitro Selection with Artificial Expanded Genetic Information Systems, Proceedings of the National Academy of Sciences, 2014, 111(4), 1449-1454.
2. Mingxu You, Lu Peng, Na Shao, Liqin Zhang, Liping Qiu, Cheng Cui and Weihong Tan, DNA "Nano-Claw": Logic-based Autonomous Cancer Targeting and Therapy, Journal of the American Chemical Society, 2014, 136(4): 1256-1259.
3. Yuan Liu, Tao Chen, Cuichen Wu, Liping Qiu, Rong Hu, Juan Li, Sena Cansiz, Liqin Zhang, Cheng Cui, Guizhi Zhu, Mingxu You, Tao Zhang, Weihong Tan, Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles, Journal of the American Chemical Society, 2014, 136(36): 12552-12555.
4. Liping Qiu, Tao Zhang, Jianhui Jiang, Cuichen Wu, Guizhi Zhu, Mingxu You, Xigao Chen, Liqin Zhang, Cheng Cui, Ruqin Yu, Weihong Tan, Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment, Journal of the American Chemical Society, 2014, 136(38): 13090-13093.
5. Juan Li, Cheng Zheng, Sena Cansiz, Cuichen Wu, Jiehua Xu, Cheng Cui, Yuan Liu, Weijia Hou, Yanyue Wang, Liqin Zhang, I-Ting Teng, Huang-Hao Yang, Weihong Tan, Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-responsive Property for Targeted Gene Therapy, Journal of the American Chemical Society, 2014, 137(4): 1412-1415.
1. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Elizabeth Jimenez, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L Gerloff, Zhen Huang, Weihong Tan, Steven A Benner. Evolution of Functional Six-Nucleotide DNA. Journal of the American Chemical Society, 2015, 111 (4), 1449-1454.

2. Liqin Zhang, Guizhi Zhu, Lei Mei, Cuichen Wu, Liping Qiu, Cheng Cui, Yuan Liu, I-Ting Teng, and Weihong Tan. Self-Assembled DNA Immuno-Nanoflowers as Multivalent CpG Nanoagents. ACS Applied Materials & Interfaces, 2015, 7 (43), 24069-24074.

3. Liqin Zhang. Unnatural Nucleic Acids for Aptamer Selection. In Aptamers Selected by Cell-SELEX for Theranostics. Xiaohong Fang, Weihong Tan, Eds.; Springer Berlin Heidelberg, 2015, pp 35-65.

4. Sena Cansiz*, Liqin Zhang*, Cuichen Wu, Yuan Wu, I-Ting Teng, Weijia Hou, Yanyue Wang, Shuo Wan, Ren Cai, Chen Jin, Qiaoling Liu, Weihong Tan. DNA Aptamer Based Nanodrugs: Molecular Engineering for Efficiency. Chemistry–An Asian Journal, 2015, 10, 2084-2094. (*co-fist authored)

5. Cuichen Wu, Shuo Wan, Weijia Hou, Liqin Zhang, Jiehua Xu, Cheng Cui, Yanyue Wang, Jun Hu, Weihong Tan, A Survey of Advancements in Nucleic Acid-Based Logic Gates and Computing for Applications in Biotechnology and Biomedicine, Chemical Communications, 2015, 51, 3723-3734.

6. Carole Champanhac, I-Ting Teng, Sena Cansiz, Liqin Zhang, Xiaoqiu Wu, Zilong Zhoa, Ting Fu, Weihong Tan. Development of a panel of DNA Aptamers with High Affinity for Pancreatic Ductal Adenocarcinoma, Scientific Reports, 2015, 5, 16788.

7. Guizhi Zhu, Sena Cansiz, Mingxu You, Liping Qiu, Ting Fu, Da Han, Liqin Zhang, Lei Mei, Tan, Weihong. Nuclease-resistant Synthetic Drug-DNA Adducts: Programmable Drug-DNA Conjugation for Targeted Anticancer Drug Delivery, NPG Asia Materials, 2015, 7, e169.

8. Cuichen Wu, Sena Cansiz, Liqin Zhang, I-Ting Teng, Liping Qiu, Juan Li, Yuan Liu, Cuisong Zhou, Rong Hu, Tao Zhang, Cheng Cui, Liang Cui, Weihong Tan. A Non-Enzymatic Hairpin DNA C

ascade Reaction Provides High Signal Gain of mRNA Imaging Inside Live Cells, Journal of the American Chemical Society, 2015, 137 (15), 4900-4903.

9. Yuan Liu, Daniel L Purich, Cuichen Wu, Yuan Wu, Tao Chen, Cheng Cui, Liqin Zhang, Sena Cansiz, Weijia Hou, Yanyue Wang, Shengyuan Yang, Weihong Tan. Ionic Functionalization of Hydrophobic Colloidal Nanoparticles to Form Ionic Nanoparticles with Enzymelike Properties, Journal of the American Chemical Society, 2015, 137 (47), 14952-14958.

10. Jiehua Xu, I-Ting Teng, Liqin Zhang, Stefanie Delgado, Carole Champanhac, Sena Cansiz, Cuichen Wu, Hong Shan, Weihong Tan. Molecular Recognition of Human Liver Cancer Cells using DNA Aptamers Generated via Cell-SELEX, Plos One, 2015, 10, e0125863.
1. Liqin Zhang, Zunyi Yang,Thu Le Trinh, I-Ting Teng, Sai Wang, Kevin M Bradley, Shuichi Hoshika, Qunfeng Wu, Sena Cansiz, Diane J Rowold, Christopher McLendon, Myong-Sang Kim, Yuan Wu, Cheng Cui, Yuan Liu, Weijia Hou, Kimberly Stewart, Shuo Wan, Chen Liu, Steven A. Benner, Weihong Tan. Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution Give Aptamers against Glypican-3-Overexpressing Tumor Cells. Angewandte Chemie International Edition, 2016, 55(40), 12372-12375.

2. Ren Cai, Dan Yang, Jin Wu, Liqin Zhang, Cuichen Wu, Xigao Chen, Yanyue Wang, Shuo Wan, Fengwei Hou, Qingyu Yan, Weihong Tan. Fabrication of Ultrathin Zn (OH)2 Nanosheets as Drug Carriers, Nano Research, 2016, 9(8), 2520-2530.

3. Juan Li, Shuxian Wu, Cuichen Wu, Liping Qiu, Guizhi Zhu, Cheng Cui, Yuan Liu, Weijia Hou, Yanyue Wang, Liqin Zhang, I-ting Teng, Huang-Hao Yang, Weihong Tan. Versatile Surface Engineering of Porous Nanomaterials with Bioinspired Polyphenol Coatings for Targeted and Controlled Drug Delivery, Nanoscale, 2016, 8, 8600-8606.

4. Ren Cai, Dan Yang, Liqin Zhang, Liping Qiu, Hao Liang, Xigao Chen, Sena Cansiz, Zuxiao Zhang, Shuo Wan, Kimberly Stewart, Qingyu Yan, Weihong Tan. A Facile Process for the Preparation of Three‐Dimensional (3D) Hollow Zn (OH)2 Nanoflowers at Room Temperature, Chemistry-A European Journal, 2016, 22, 11143-11147.

5. Yifan Lyu, Guang Chen, Dihua Shangguan, Liqin Zhang, Shuo Wan, Yuan Wu, Hui Zhang, Lian Duan, Chao Liu, Mingxu You, Jie Wang, Weihong Tan. Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX, Theranostics, 2016, 6(9), 1440-1452.

6. Yanyue Wang, Cuichen Wu, Tao Chen, Hao Sun, Sena Cansiz, Liqin Zhang, Cheng Cui, Weijia Hou, Yuan Wu, Shuo Wan, Ren Cai, Yuan Liu, Brent S Sumerlin, Xiaobing Zhang, Weihong Tan. DNA Micelle Flares: A Study of the Basic Properties that Contribute to Enhanced Stability and Binding Affinity in Complex Biological Systems. Chemical Science, 2016,7, 6041-6049.

7. Shanshan Wang, Zhangkun Liu, Yuxiu Zou, Xiaofang Lai, Ding Ding, Long Chen, Liqin Zhang, Yuan Wu, Zhuo Chen, Weihong Tan. Elucidating the Cellular Uptake Mechanism of Aptamer-Functionalized Graphene- Isolated-Au-Nanocrystals with Dual-Modal Imaging, Analyst, 2016, 141, 3337-3342.

1. Liqin Zhang, Shuo Wan, Ying Jiang, Yanyue Wang, Ting Fu, Qiaoling Liu, Zhijuan Cao, Liping Qiu, and Weihong Tan. Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology. Journal of the American Chemical Society, 2017, 139 (7), 2532–2540.
2. Shuo Wan#, Liqin Zhang#, Sai Wang, Sena Cansiz, Hui Zhang, Yuan Liu, Cheng Cui, Weihong Tan, DNA Nanoassembly on exosome Membrane Surfaces for Enhanced Fluorescent Detection. Journal of the American Chemical Society, 2017, 139 (15), 5289-5292. (#co-fist authored)

3. Sai Wang#, Liqin Zhang#, Shuo Wan, Sena Cansiz, Yuan Liu, Ren Cai, Cheng-Yi Hong, I-Ting Teng, Muling Shi, Yuan Wu, Yiyang Dong, and Weihong Tan, Aptasensor with Expanded Nucleotide using DNA Nanotetrahedra for Electrochemical Detection of Cancerous Exosomes.  ACS Nano, 2017, 11 (4), 3943-394911. (#co-fist authored)

4. Ke Chen, Bo Liu, Bo Yu, Wen Zhong, Yi Lu, Jiani Zhang, Jie Liao, Jun Liu, Ying Pu, Liping Qiu, Liqin Zhang, Huixia Liu, Weihong Tan. Advances in the development of aptamer drug conjugates for targeted drug delivery, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017, 9(3), e0125863.

5. Yun Huang, Harry C Pappas, Liqin Zhang, Shanshan Wang, Ren Cai, Weihong Tan, Shu Wang, David G Whitten, Kirk S Schanze. Selective Imaging and Inactivation of Bacteria over Mammalian Cells by Imidazolium-Substituted Polythiophene, Chemistry of Materials, 2017, 29(15), 6389-6395.
6. Mingxu You, Yifan Lyu, Da Han, Liping Qiu, Qiaoling Liu, Tao Chen, Cuichen Sam Wu, Lu Peng, Liqin Zhang, Gang Bao and Weihong Tan, A DNA Probe for Monitoring Dynamic and Transient Molecular Encounters on Live Cell Membranes, Nature Nanotechnology, 2017, 12, 453-459.
7. Ying Jiang, Muling Shi, Yuan Liu, Shuo Wan, Cheng Cui, Liqin Zhang, Weihong Tan, Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins, Angewandte Chemie International Edition, 2017, 56(39), 11916-11920.
8. Yuan Liu, Weijia Hou, Hao Sun, Cheng Cui, Liqin Zhang, Ying Jiang, Yongxiang Wu, Yanyue Wang, Juan Li, Brent S Sumerlin, Qiaoling Liu, Weihong Tan. Thiol–ene click chemistry: a biocompatible way for orthogonal bioconjugation of colloidal nanoparticles, Chemical Science, 2017, 8(9), 6182-6187.

1. Weijia Hou, Yuan Liu, Ying Jiang, Yuan Wu, Cheng Cui, Yanyue Wang, Liqin Zhang, I-Ting Teng, Weihong Tan. Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging, Nanoscale, 2018, 10, 10986-10990.

2. Jin Li, Liping Qiu, Sitao Xie, Jing Zhang, Liqin Zhang, Honglin Liu, Juan Li, Xiaobing Zhang, Weihong Tan. Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy, Science China Chemistry, 2018, 61(4), 497–504.

3. Yifan Lyu, I-Ting Teng, Liqin Zhang, Yian Guo, Ren Cai, Xiaobing Zhang, Liping Qiu, Weihong Tan. A comprehensive regression model for dissociation equilibria of cell-specific aptamers. Analytical Chemistry, 2018, 90(17), 10487–10493.

4. Wanghua Wu, Tao Zhang, Da Han, Hongliang Fan, Guizhi Zhu, Xiong Ding, Cuichen Wu, Mingxu You, Liping Qiu, Juan Li, Liqin Zhang, Xiang Lian, Rong Hu, Ying Mu, Jianguang Zhou, Weihong Tan. Aligner-mediated cleavage of nucleic acids and its application to isothermal exponential amplification. Chemical Science, 2018, 9, 3050-3055.

5. Yuan Wu, Liqin Zhang, Cheng Cui, Sena Cansiz, Hao Liang, Cuichen Wu, I-Ting Teng, Weijun Chen, Yuan Liu, Weijia Hou, Xiaobing Zhang, Weihong Tan. Journal of the American Chemical Society, 2018, 140 (1): 2–5.

1. Lianhui Zhao, Xiaoyan Qi, Xiaochen Yan, Yunfei Huang, Xingguo Liang, Liqin Zhang*, Sai Wang*, Weihong Tan*. Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation. Journal of the American Chemical Society, 2019, 141 (44), 17493-17497. (*co-corresponding authored)

2. Jie Tan, Mengmeng Zhao, Jie Wang, Zhihao Li, Ling Liang, Liqin Zhang, Quan Yuan, Weihong Tan.  Regulation of Protein Activity and Cellular Functions Mediated by Molecularly Evolved Nucleic Acids, Angewandte Chemie International Edition, 2019, 131(6), 1635-1639.

1. Liqin Zhang, Sai Wang, Zunyi Yang, Shuichi Hoshika, Sitao Xie, Jin Li, Xigao Chen, Shuo Wan, Long Li, Steven A Benner, Weihong Tan. An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells, Angewandte Chemie International Edition, 2020, 132 (2), 673-678.

2. Jun Li, Yao-Yao Fan, Man Wang, Hui-Ling Duan, Jing Zhang, Fuquan Dang, Liqin Zhang*, Zhi-Qi Zhang*. A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-Ι RNA-Binding Small Molecules. Analytical Chemistry, 2020, 92(19), 13532-13538.